In a study, researchers investigated the molecular mechanisms of state anxiety in chemotherapy-treated patients with cancer. Forty-one perturbed signaling pathways were identified, including eight overlapping with those found in anxiolytic compound studies. The findings reveal the biological underpinnings of chemotherapy-induced anxiety, suggesting similarities with anxiety in other conditions and informing future research and treatment strategies.

Reference: Oppegaard K, Kober KM, Harris C, et al. Anxiety in oncology outpatients is associated with perturbations in pathways identified in anxiety focused network pharmacology research. Support Care Cancer. 2023;31(12):727. doi:10.1007/s00520-023-08196-2